Conjugation of the Ubiquitin Activating Enzyme UBE1 with the Ubiquitin-Like Modifier FAT10 Targets It for Proteasomal Degradation

The ubiquitin-like modifier HLA-F adjacent transcript 10 (FAT10) directly targets its substrates for proteasomal degradation by becoming covalently attached via its C-terminal diglycine motif to internal lysine residues of its substrate proteins. The conjugation machinery consists of the bispecific...

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Detalles Bibliográficos
Autores principales: Bialas, Johanna, Groettrup, Marcus, Aichem, Annette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359146/
https://www.ncbi.nlm.nih.gov/pubmed/25768649
http://dx.doi.org/10.1371/journal.pone.0120329

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359146/
https://www.ncbi.nlm.nih.gov/pubmed/25768649
http://dx.doi.org/10.1371/journal.pone.0120329

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