Lysosomal sequestration of hydrophobic weak base chemotherapeutics triggers lysosomal biogenesis and lysosome-dependent cancer multidrug resistance

Multidrug resistance (MDR) is a primary hindrance to curative cancer chemotherapy. In this respect, lysosomes were suggested to play a role in intrinsic MDR by sequestering protonated hydrophobic weak base chemotherapeutics away from their intracellular target sites. Here we show that intrinsic resi...

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Detalles Bibliográficos
Autores principales: Zhitomirsky, Benny, Assaraf, Yehuda G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359223/
https://www.ncbi.nlm.nih.gov/pubmed/25544758

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359223/
https://www.ncbi.nlm.nih.gov/pubmed/25544758

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