The TLR7 agonist induces tumor regression both by promoting CD4(+)T cells proliferation and by reversing T regulatory cell-mediated suppression via dendritic cells

Treg-induced immunosuppression is now recognized as a key element in enabling tumors to escape immune-mediated destruction. Although topical TLR7 therapies such as imiquimod have been proved successful in the treatment of dermatological malignancy and a number of conditions beyond the FDA-approved i...

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Detalles Bibliográficos
Autores principales: Wang, Chenchen, Zhou, Quan, Wang, Xiaofeng, Wu, Xiongyan, Chen, Xuehua, Li, Jianfang, Zhu, Zhenggang, Liu, Bingya, Su, Liping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359331/
https://www.ncbi.nlm.nih.gov/pubmed/25593198

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359331/
https://www.ncbi.nlm.nih.gov/pubmed/25593198

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