Lis1 regulates dynein by sterically blocking its mechanochemical cycle

Regulation of cytoplasmic dynein's motor activity is essential for diverse eukaryotic functions, including cell division, intracellular transport, and brain development. The dynein regulator Lis1 is known to keep dynein bound to microtubules; however, how this is accomplished mechanistically re...

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Detalles Bibliográficos
Autores principales: Toropova, Katerina, Zou, Sirui, Roberts, Anthony J, Redwine, William B, Goodman, Brian S, Reck-Peterson, Samara L, Leschziner, Andres E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359366/
https://www.ncbi.nlm.nih.gov/pubmed/25380312
http://dx.doi.org/10.7554/eLife.03372

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359366/
https://www.ncbi.nlm.nih.gov/pubmed/25380312
http://dx.doi.org/10.7554/eLife.03372

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