DNA binding polarity, dimerization, and ATPase ring remodeling in the CMG helicase of the eukaryotic replisome

The Cdc45/Mcm2-7/GINS (CMG) helicase separates DNA strands during replication in eukaryotes. How the CMG is assembled and engages DNA substrates remains unclear. Using electron microscopy, we have determined the structure of the CMG in the presence of ATPγS and a DNA duplex bearing a 3′ single-stran...

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Detalles Bibliográficos
Autores principales: Costa, Alessandro, Renault, Ludovic, Swuec, Paolo, Petojevic, Tatjana, Pesavento, James J, Ilves, Ivar, MacLellan-Gibson, Kirsty, Fleck, Roland A, Botchan, Michael R, Berger, James M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359367/
https://www.ncbi.nlm.nih.gov/pubmed/25117490
http://dx.doi.org/10.7554/eLife.03273

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359367/
https://www.ncbi.nlm.nih.gov/pubmed/25117490
http://dx.doi.org/10.7554/eLife.03273

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