Therapeutic properties of a vector carrying the HSV thymidine kinase and GM-CSF genes and delivered as a complex with a cationic copolymer

BACKGROUND: Gene-directed enzyme prodrug therapy (GDEPT) represents a technology to improve drug selectivity for cancer cells. It consists of delivery into tumor cells of a suicide gene responsible for in situ conversion of a prodrug into cytotoxic metabolites. Major limitations of GDEPT that hinder...

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Detalles Bibliográficos
Autores principales: Alekseenko, Irina V, Snezhkov, Eugene V, Chernov, Igor P, Pleshkan, Victor V, Potapov, Victor K, Sass, Alexander V, Monastyrskaya, Galina S, Kopantzev, Eugene P, Vinogradova, Tatyana V, Khramtsov, Yuri V, Ulasov, Alexey V, Rosenkranz, Andrey A, Sobolev, Alexander S, Bezborodova, Olga A, Plyutinskaya, Anna D, Nemtsova, Elena R, Yakubovskaya, Raisa I, Sverdlov, Eugene D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359447/
https://www.ncbi.nlm.nih.gov/pubmed/25880666
http://dx.doi.org/10.1186/s12967-015-0433-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359447/
https://www.ncbi.nlm.nih.gov/pubmed/25880666
http://dx.doi.org/10.1186/s12967-015-0433-0

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