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Therapeutic properties of a vector carrying the HSV thymidine kinase and GM-CSF genes and delivered as a complex with a cationic copolymer
BACKGROUND: Gene-directed enzyme prodrug therapy (GDEPT) represents a technology to improve drug selectivity for cancer cells. It consists of delivery into tumor cells of a suicide gene responsible for in situ conversion of a prodrug into cytotoxic metabolites. Major limitations of GDEPT that hinder...
Autores principales: | Alekseenko, Irina V, Snezhkov, Eugene V, Chernov, Igor P, Pleshkan, Victor V, Potapov, Victor K, Sass, Alexander V, Monastyrskaya, Galina S, Kopantzev, Eugene P, Vinogradova, Tatyana V, Khramtsov, Yuri V, Ulasov, Alexey V, Rosenkranz, Andrey A, Sobolev, Alexander S, Bezborodova, Olga A, Plyutinskaya, Anna D, Nemtsova, Elena R, Yakubovskaya, Raisa I, Sverdlov, Eugene D |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359447/ https://www.ncbi.nlm.nih.gov/pubmed/25880666 http://dx.doi.org/10.1186/s12967-015-0433-0 |
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