Inhibition of SHP2 in basal-like and triple-negative breast cells induces basal-to-luminal transition, hormone dependency, and sensitivity to anti-hormone treatment

BACKGROUND: The Src homology phosphotyrosyl phosphatase 2 (SHP2) is a positive effector of cell growth and survival signaling as well transformation induced by multiple tyrosine kinase oncogenes. Since the basal-like and triple-negative breast cancer (BTBC) is characterized by dysregulation of multi...

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Detalles Bibliográficos
Autores principales: Zhao, Hua, Agazie, Yehenew M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359540/
https://www.ncbi.nlm.nih.gov/pubmed/25885600
http://dx.doi.org/10.1186/s12885-015-1131-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359540/
https://www.ncbi.nlm.nih.gov/pubmed/25885600
http://dx.doi.org/10.1186/s12885-015-1131-2

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