Structural chromosome abnormalities, increased DNA strand breaks and DNA strand break repair deficiency in dermal fibroblasts from old female human donors

Dermal fibroblasts provide a paradigmatic model of cellular adaptation to long-term exogenous stress and ageing processes driven thereby. Here we addressed whether fibroblast ageing analysed ex vivo entails genome instability. Dermal fibroblasts from human female donors aged 20–67 years were studied...

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Detalles Bibliográficos
Autores principales: Kalfalah, Faiza, Seggewiß, Sabine, Walter, Regina, Tigges, Julia, Moreno-Villanueva, María, Bürkle, Alexander, Ohse, Sebastian, Busch, Hauke, Boerries, Melanie, Hildebrandt, Barbara, Royer-Pokora, Brigitte, Boege, Fritz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359693/
https://www.ncbi.nlm.nih.gov/pubmed/25678531

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359693/
https://www.ncbi.nlm.nih.gov/pubmed/25678531

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