TRPA1 as a drug target—promise and challenges

The transient receptor potential ankyrin 1 (TRPA1) channel is a nonselective cation channel belonging to the superfamily of transient receptor potential (TRP) channels. It is predominantly expressed in sensory neurons and serves as an irritant sensor for a plethora of electrophilic compounds. Recent...

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Detalles Bibliográficos
Autores principales: Chen, Jun, Hackos, David H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359712/
https://www.ncbi.nlm.nih.gov/pubmed/25640188
http://dx.doi.org/10.1007/s00210-015-1088-3
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author Chen, Jun
Hackos, David H.
author_facet Chen, Jun
Hackos, David H.
author_sort Chen, Jun
collection PubMed
description The transient receptor potential ankyrin 1 (TRPA1) channel is a nonselective cation channel belonging to the superfamily of transient receptor potential (TRP) channels. It is predominantly expressed in sensory neurons and serves as an irritant sensor for a plethora of electrophilic compounds. Recent studies suggest that TRPA1 is involved in pain, itch, and respiratory diseases, and TRPA1 antagonists have been actively pursued as therapeutic agents. Here, we review the recent progress, unsettled issues, and challenges in TRPA1 research and drug discovery.
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spelling pubmed-43597122015-03-18 TRPA1 as a drug target—promise and challenges Chen, Jun Hackos, David H. Naunyn Schmiedebergs Arch Pharmacol Review The transient receptor potential ankyrin 1 (TRPA1) channel is a nonselective cation channel belonging to the superfamily of transient receptor potential (TRP) channels. It is predominantly expressed in sensory neurons and serves as an irritant sensor for a plethora of electrophilic compounds. Recent studies suggest that TRPA1 is involved in pain, itch, and respiratory diseases, and TRPA1 antagonists have been actively pursued as therapeutic agents. Here, we review the recent progress, unsettled issues, and challenges in TRPA1 research and drug discovery. Springer Berlin Heidelberg 2015-02-03 2015 /pmc/articles/PMC4359712/ /pubmed/25640188 http://dx.doi.org/10.1007/s00210-015-1088-3 Text en © The Author(s) 2015 https://creativecommons.org/licenses/by/4.0/ Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Review
Chen, Jun
Hackos, David H.
TRPA1 as a drug target—promise and challenges
title TRPA1 as a drug target—promise and challenges
title_full TRPA1 as a drug target—promise and challenges
title_fullStr TRPA1 as a drug target—promise and challenges
title_full_unstemmed TRPA1 as a drug target—promise and challenges
title_short TRPA1 as a drug target—promise and challenges
title_sort trpa1 as a drug target—promise and challenges
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359712/
https://www.ncbi.nlm.nih.gov/pubmed/25640188
http://dx.doi.org/10.1007/s00210-015-1088-3
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