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Development of a new approach for targeted gene editing in primordial germ cells using TALENs in Xenopus
A gene of interest can be efficiently modified using transcription activator-like effector nucleases (TALENs) (Christian et al., 2010;Li et al., 2011). However, if a target gene is essential for development, growth and fertility, use of TALENs with high mutagenic activity in F0 frogs could result in...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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The Company of Biologists
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359732/ https://www.ncbi.nlm.nih.gov/pubmed/25661867 http://dx.doi.org/10.1242/bio.201410926 |