AZT resistance alters enzymatic properties and creates an ATP-binding site in SFVmac reverse transcriptase

BACKGROUND: The replication of simian foamy virus from macaques can be inhibited by the nucleoside reverse transcriptase inhibitor azidothymidine (AZT, zidovudine). Four substitutions in the protease-reverse transcriptase (PR-RT) protein (K211I, I224T, S345T, E350K) are necessary to obtain highly AZ...

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Detalles Bibliográficos
Autores principales: Schneider, Anna, Schweimer, Kristian, Rösch, Paul, Wöhrl, Birgitta M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359774/
https://www.ncbi.nlm.nih.gov/pubmed/25808094
http://dx.doi.org/10.1186/s12977-015-0147-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359774/
https://www.ncbi.nlm.nih.gov/pubmed/25808094
http://dx.doi.org/10.1186/s12977-015-0147-7

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