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AZT resistance alters enzymatic properties and creates an ATP-binding site in SFVmac reverse transcriptase

BACKGROUND: The replication of simian foamy virus from macaques can be inhibited by the nucleoside reverse transcriptase inhibitor azidothymidine (AZT, zidovudine). Four substitutions in the protease-reverse transcriptase (PR-RT) protein (K211I, I224T, S345T, E350K) are necessary to obtain highly AZ...

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Detalles Bibliográficos
Autores principales:	Schneider, Anna, Schweimer, Kristian, Rösch, Paul, Wöhrl, Birgitta M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359774/ https://www.ncbi.nlm.nih.gov/pubmed/25808094 http://dx.doi.org/10.1186/s12977-015-0147-7

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