Effective Binding of a Phosphatidylserine-Targeting Antibody to Ebola Virus Infected Cells and Purified Virions

Ebola virus is responsible for causing severe hemorrhagic fevers, with case fatality rates of up to 90%. Currently, no antiviral or vaccine is licensed against Ebola virus. A phosphatidylserine-targeting antibody (PGN401, bavituximab) has previously been shown to have broad-spectrum antiviral activi...

Descripción completa

Detalles Bibliográficos
Autores principales: Dowall, S. D., Graham, V. A., Corbin-Lickfett, K., Empig, C., Schlunegger, K., Bruce, C. B., Easterbrook, L., Hewson, R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359806/
https://www.ncbi.nlm.nih.gov/pubmed/25815346
http://dx.doi.org/10.1155/2015/347903
_version_ 1782361470867079168
author Dowall, S. D.
Graham, V. A.
Corbin-Lickfett, K.
Empig, C.
Schlunegger, K.
Bruce, C. B.
Easterbrook, L.
Hewson, R.
author_facet Dowall, S. D.
Graham, V. A.
Corbin-Lickfett, K.
Empig, C.
Schlunegger, K.
Bruce, C. B.
Easterbrook, L.
Hewson, R.
author_sort Dowall, S. D.
collection PubMed
description Ebola virus is responsible for causing severe hemorrhagic fevers, with case fatality rates of up to 90%. Currently, no antiviral or vaccine is licensed against Ebola virus. A phosphatidylserine-targeting antibody (PGN401, bavituximab) has previously been shown to have broad-spectrum antiviral activity. Here, we demonstrate that PGN401 specifically binds to Ebola virus and recognizes infected cells. Our study provides the first evidence of phosphatidylserine-targeting antibody reactivity against Ebola virus.
format Online
Article
Text
id pubmed-4359806
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-43598062015-03-26 Effective Binding of a Phosphatidylserine-Targeting Antibody to Ebola Virus Infected Cells and Purified Virions Dowall, S. D. Graham, V. A. Corbin-Lickfett, K. Empig, C. Schlunegger, K. Bruce, C. B. Easterbrook, L. Hewson, R. J Immunol Res Research Article Ebola virus is responsible for causing severe hemorrhagic fevers, with case fatality rates of up to 90%. Currently, no antiviral or vaccine is licensed against Ebola virus. A phosphatidylserine-targeting antibody (PGN401, bavituximab) has previously been shown to have broad-spectrum antiviral activity. Here, we demonstrate that PGN401 specifically binds to Ebola virus and recognizes infected cells. Our study provides the first evidence of phosphatidylserine-targeting antibody reactivity against Ebola virus. Hindawi Publishing Corporation 2015 2015-03-01 /pmc/articles/PMC4359806/ /pubmed/25815346 http://dx.doi.org/10.1155/2015/347903 Text en Copyright © 2015 S. D. Dowall et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Dowall, S. D.
Graham, V. A.
Corbin-Lickfett, K.
Empig, C.
Schlunegger, K.
Bruce, C. B.
Easterbrook, L.
Hewson, R.
Effective Binding of a Phosphatidylserine-Targeting Antibody to Ebola Virus Infected Cells and Purified Virions
title Effective Binding of a Phosphatidylserine-Targeting Antibody to Ebola Virus Infected Cells and Purified Virions
title_full Effective Binding of a Phosphatidylserine-Targeting Antibody to Ebola Virus Infected Cells and Purified Virions
title_fullStr Effective Binding of a Phosphatidylserine-Targeting Antibody to Ebola Virus Infected Cells and Purified Virions
title_full_unstemmed Effective Binding of a Phosphatidylserine-Targeting Antibody to Ebola Virus Infected Cells and Purified Virions
title_short Effective Binding of a Phosphatidylserine-Targeting Antibody to Ebola Virus Infected Cells and Purified Virions
title_sort effective binding of a phosphatidylserine-targeting antibody to ebola virus infected cells and purified virions
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4359806/
https://www.ncbi.nlm.nih.gov/pubmed/25815346
http://dx.doi.org/10.1155/2015/347903
work_keys_str_mv AT dowallsd effectivebindingofaphosphatidylserinetargetingantibodytoebolavirusinfectedcellsandpurifiedvirions
AT grahamva effectivebindingofaphosphatidylserinetargetingantibodytoebolavirusinfectedcellsandpurifiedvirions
AT corbinlickfettk effectivebindingofaphosphatidylserinetargetingantibodytoebolavirusinfectedcellsandpurifiedvirions
AT empigc effectivebindingofaphosphatidylserinetargetingantibodytoebolavirusinfectedcellsandpurifiedvirions
AT schluneggerk effectivebindingofaphosphatidylserinetargetingantibodytoebolavirusinfectedcellsandpurifiedvirions
AT brucecb effectivebindingofaphosphatidylserinetargetingantibodytoebolavirusinfectedcellsandpurifiedvirions
AT easterbrookl effectivebindingofaphosphatidylserinetargetingantibodytoebolavirusinfectedcellsandpurifiedvirions
AT hewsonr effectivebindingofaphosphatidylserinetargetingantibodytoebolavirusinfectedcellsandpurifiedvirions

Ejemplares similares