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Enhanced inflammation in aged mice following infection with Streptococcus pneumoniae is associated with decreased IL-10 and augmented chemokine production

Streptococcus pneumoniae is the most common cause of severe pneumonia in the elderly. However, the impact of aging on the innate inflammatory response to pneumococci is poorly defined. We compared the innate immune response in old vs. young adult mice following infection with S. pneumoniae. The accu...

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Detalles Bibliográficos
Autores principales: Williams, Andrew E., José, Ricardo J., Brown, Jeremy S., Chambers, Rachel C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Physiological Society 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360060/
https://www.ncbi.nlm.nih.gov/pubmed/25595646
http://dx.doi.org/10.1152/ajplung.00141.2014