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Antidepressant Effects of TrkB Ligands on Depression-Like Behavior and Dendritic Changes in Mice After Inflammation

BACKGROUND: Brain-derived neurotrophic factor (BDNF) and its receptor, tropomyosin-related kinase B (TrkB), signaling represent potential therapeutic targets for major depressive disorder. The purpose of this study is to examine whether TrkB ligands show antidepressant effects in an inflammation-ind...

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Detalles Bibliográficos
Autores principales: Zhang, Ji-chun, Wu, Jin, Fujita, Yuko, Yao, Wei, Ren, Qian, Yang, Chun, Li, Su-xia, Shirayama, Yukihiko, Hashimoto, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360225/
https://www.ncbi.nlm.nih.gov/pubmed/25628381
http://dx.doi.org/10.1093/ijnp/pyu077