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5-HT(2C) Receptor Desensitization Moderates Anxiety in 5-HTT Deficient Mice: From Behavioral to Cellular Evidence
BACKGROUND: Desensitization and blockade of 5-HT(2C) receptors (5-HT(2C)R) have long been thought to be central in the therapeutic action of antidepressant drugs. However, besides behavioral pharmacology studies, there is little in vivo data documenting antidepressant-induced 5-HT(2C)R desensitizati...
Autores principales: | Martin, Cédric BP, Martin, Vincent S., Trigo, José M., Chevarin, Caroline, Maldonado, Rafael, Fink, Latham H., Cunningham, Kathryn A., Hamon, Michel, Lanfumey, Laurence, Mongeau, Raymond |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360241/ https://www.ncbi.nlm.nih.gov/pubmed/25522398 http://dx.doi.org/10.1093/ijnp/pyu056 |
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