A Binding Mode Hypothesis of Tiagabine Confirms Liothyronine Effect on γ-Aminobutyric Acid Transporter 1 (GAT1)

[Image: see text] Elevating GABA levels in the synaptic cleft by inhibiting its reuptake carrier GAT1 is an established approach for the treatment of CNS disorders like epilepsy. With the increasing availability of crystal structures of transmembrane transporters, structure-based approaches to eluci...

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Detalles Bibliográficos
Autores principales: Jurik, Andreas, Zdrazil, Barbara, Holy, Marion, Stockner, Thomas, Sitte, Harald H., Ecker, Gerhard F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360375/
https://www.ncbi.nlm.nih.gov/pubmed/25679268
http://dx.doi.org/10.1021/jm5015428

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360375/
https://www.ncbi.nlm.nih.gov/pubmed/25679268
http://dx.doi.org/10.1021/jm5015428

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