Secreted CLCA1 modulates TMEM16A to activate Ca(2+)-dependent chloride currents in human cells

Calcium-activated chloride channel regulator 1 (CLCA1) activates calcium-dependent chloride currents; neither the target, nor mechanism, is known. We demonstrate that secreted CLCA1 activates calcium-dependent chloride currents in HEK293T cells in a paracrine fashion, and endogenous TMEM16A/Anoctami...

Descripción completa

Detalles Bibliográficos
Autores principales: Sala-Rabanal, Monica, Yurtsever, Zeynep, Nichols, Colin G, Brett, Tom J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Biophysics and Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360653/
https://www.ncbi.nlm.nih.gov/pubmed/25781344
http://dx.doi.org/10.7554/eLife.05875

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360653/
https://www.ncbi.nlm.nih.gov/pubmed/25781344
http://dx.doi.org/10.7554/eLife.05875

Ejemplares similares