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Secreted CLCA1 modulates TMEM16A to activate Ca(2+)-dependent chloride currents in human cells

Calcium-activated chloride channel regulator 1 (CLCA1) activates calcium-dependent chloride currents; neither the target, nor mechanism, is known. We demonstrate that secreted CLCA1 activates calcium-dependent chloride currents in HEK293T cells in a paracrine fashion, and endogenous TMEM16A/Anoctami...

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Detalles Bibliográficos
Autores principales:	Sala-Rabanal, Monica, Yurtsever, Zeynep, Nichols, Colin G, Brett, Tom J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2015
Materias:	Biophysics and Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360653/ https://www.ncbi.nlm.nih.gov/pubmed/25781344 http://dx.doi.org/10.7554/eLife.05875

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