Graded Ca(2+)/calmodulin-dependent coupling of voltage-gated Ca(V)1.2 channels

In the heart, reliable activation of Ca(2+) release from the sarcoplasmic reticulum during the plateau of the ventricular action potential requires synchronous opening of multiple Ca(V)1.2 channels. Yet the mechanisms that coordinate this simultaneous opening during every heartbeat are unclear. Here...

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Detalles Bibliográficos
Autores principales: Dixon, Rose E, Moreno, Claudia M, Yuan, Can, Opitz-Araya, Ximena, Binder, Marc D, Navedo, Manuel F, Santana, Luis F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Biophysics and Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360655/
https://www.ncbi.nlm.nih.gov/pubmed/25714924
http://dx.doi.org/10.7554/eLife.05608

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360655/
https://www.ncbi.nlm.nih.gov/pubmed/25714924
http://dx.doi.org/10.7554/eLife.05608

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