Development of a Pediatric Physiologically Based Pharmacokinetic Model for Sirolimus: Applying Principles of Growth and Maturation in Neonates and Infants

This study describes the maturation of sirolimus clearance in a cohort of very young pediatric patients with vascular anomalies. The relationship between allometrically scaled in vivo clearance and age was described by the E(max) model in patients aged 1 month to 2 years. Consistent with the observe...

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Detalles Bibliográficos
Autores principales: Emoto, C, Fukuda, T, Johnson, TN, Adams, DM, Vinks, AA
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360665/
https://www.ncbi.nlm.nih.gov/pubmed/26225230
http://dx.doi.org/10.1002/psp4.17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360665/
https://www.ncbi.nlm.nih.gov/pubmed/26225230
http://dx.doi.org/10.1002/psp4.17

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