A Systems Pharmacology Model of Erythropoiesis in Mice Induced by Small Molecule Inhibitor of Prolyl Hydroxylase Enzymes

Mammalian erythropoiesis is a conserved process tightly controlled by the hypoxia-inducible factor (HIF1) pathway. In this study, a small molecule inhibitor (PHI-1) of prolyl-hydroxylase-2 (PHD2) enzyme involved in regulating HIF1α levels was orally administered to male BALB/c mice at 10 and 30 mg/k...

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Detalles Bibliográficos
Autores principales: Singh, I, Nagiec, EE, Thompson, JM, Krzyzanski, W, Singh, P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360669/
https://www.ncbi.nlm.nih.gov/pubmed/26225228
http://dx.doi.org/10.1002/psp4.12

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360669/
https://www.ncbi.nlm.nih.gov/pubmed/26225228
http://dx.doi.org/10.1002/psp4.12

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