The recombinant adeno-associated virus vector (rAAV2)-mediated apolipoprotein B mRNA-specific hammerhead ribozyme: a self-complementary AAV2 vector improves the gene expression

BACKGROUND: In humans, overproduction of apolipoprotein B (apoB) is positively associated with premature coronary artery diseases. To reduce the levels of apoB mRNA, we have designed an apoB mRNA-specific hammerhead ribozyme targeted at nucleotide sequences GUA(6679 )(RB15) mediated by adenovirus, w...

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Detalles Bibliográficos
Autores principales: Zhong, Shumei, Sun, Shihua, Teng, Ba-Bie
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2004
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC436067/
https://www.ncbi.nlm.nih.gov/pubmed/15193153
http://dx.doi.org/10.1186/1479-0556-2-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC436067/
https://www.ncbi.nlm.nih.gov/pubmed/15193153
http://dx.doi.org/10.1186/1479-0556-2-5

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