Canine helper-dependent vectors production: implications of Cre activity and co-infection on adenovirus propagation

The importance of Cre recombinase to minimize helper vector (HV) contamination during helper-dependent adenovirus vectors (HDVs) production is well documented. However, Cre recombinase, by inducing DNA double-strand breaks (DSBs), can cause a reduced proliferation and genotoxic effects in cultured c...

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Detalles Bibliográficos
Autores principales: Fernandes, Paulo, Almeida, Ana I., Kremer, Eric J., Alves, Paula M., Coroadinha, Ana S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360735/
https://www.ncbi.nlm.nih.gov/pubmed/25774853
http://dx.doi.org/10.1038/srep09135

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4360735/
https://www.ncbi.nlm.nih.gov/pubmed/25774853
http://dx.doi.org/10.1038/srep09135

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