ANKS6 is the critical activator of NEK8 kinase in embryonic situs determination and organ patterning

The ciliary kinase NEK8 plays a critical role in situs determination and cystic kidney disease, yet its exact function remains unknown. In this study we identify ANKS6 as a target and activator of NEK8. ANKS6 requires NEK8 for localizing to the ciliary inversin compartment (IC) and activates NEK8 by...

Descripción completa

Detalles Bibliográficos
Autores principales: Czarnecki, Peter G., Gabriel, George C., Manning, Danielle K., Sergeev, Mikhail, Lemke, Kristi, Klena, Nikolai T., Liu, Xiaoqin, Chen, Yu, Li, You, San Agustin, Jovenal T., Garnaas, Maija K., Francis, Richard J., Tobita, Kimimasa, Goessling, Wolfram, Pazour, Gregory J., Lo, Cecilia W., Beier, David R., Shah, Jagesh V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361001/
https://www.ncbi.nlm.nih.gov/pubmed/25599650
http://dx.doi.org/10.1038/ncomms7023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361001/
https://www.ncbi.nlm.nih.gov/pubmed/25599650
http://dx.doi.org/10.1038/ncomms7023

Ejemplares similares