Destruction of Full-Length Androgen Receptor by Wild-Type SPOP, but Not Prostate-Cancer-Associated Mutants

The SPOP E3 ubiquitin ligase gene is frequently mutated in human prostate cancers. Here, we demonstrate that SPOP recognizes a Ser/Thr-rich degron in the hinge domain of androgen receptor (AR)and induces degradation of full-length AR and inhibition of AR-mediated gene transcription and prostate canc...

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Detalles Bibliográficos
Autores principales: An, Jian, Wang, Chenji, Deng, Yibin, Yu, Long, Huang, Haojie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361392/
https://www.ncbi.nlm.nih.gov/pubmed/24508459
http://dx.doi.org/10.1016/j.celrep.2014.01.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361392/
https://www.ncbi.nlm.nih.gov/pubmed/24508459
http://dx.doi.org/10.1016/j.celrep.2014.01.013

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