The 1.7 Å X-Ray Crystal Structure of the Porcine Factor VIII C2 Domain and Binding Analysis to Anti-Human C2 Domain Antibodies and Phospholipid Surfaces

The factor VIII C2 domain is essential for binding to activated platelet surfaces as well as the cofactor activity of factor VIII in blood coagulation. Inhibitory antibodies against the C2 domain commonly develop following factor VIII replacement therapy for hemophilia A patients, or they may sponta...

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Detalles Bibliográficos
Autores principales: Brison, Caileen M., Mullen, Steven M., Wuerth, Michelle E., Podolsky, Kira, Cook, Matthew, Herman, Jacob A., Walter, Justin D., Meeks, Shannon L., Spiegel, P. Clint
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361576/
https://www.ncbi.nlm.nih.gov/pubmed/25775247
http://dx.doi.org/10.1371/journal.pone.0122447

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361576/
https://www.ncbi.nlm.nih.gov/pubmed/25775247
http://dx.doi.org/10.1371/journal.pone.0122447

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