Protein Expression of DNA Damage Repair Proteins Dictates Response to Topoisomerase and PARP Inhibitors in Triple-Negative Breast Cancer

Patients with metastatic triple-negative breast cancer (TNBC) have a poor prognosis. New approaches for the treatment of TNBC are needed to improve patient survival. The concept of synthetic lethality, brought about by inactivating complementary DNA repair pathways, has been proposed as a promising...

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Detalles Bibliográficos
Autores principales: Boerner, Julie L., Nechiporchik, Nicole, Mueller, Kelly L., Polin, Lisa, Heilbrun, Lance, Boerner, Scott A., Zoratti, Gina L., Stark, Karri, LoRusso, Patricia M., Burger, Angelika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361640/
https://www.ncbi.nlm.nih.gov/pubmed/25774912
http://dx.doi.org/10.1371/journal.pone.0119614

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361640/
https://www.ncbi.nlm.nih.gov/pubmed/25774912
http://dx.doi.org/10.1371/journal.pone.0119614

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