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Effect of Dopaminergic D1 Receptors on Plasticity Is Dependent of Serotoninergic 5-HT1A Receptors in L5-Pyramidal Neurons of the Prefrontal Cortex

Major depression and schizophrenia are associated with dysfunctions of serotoninergic and dopaminergic systems mainly in the prefrontal cortex (PFC). Both serotonin and dopamine are known to modulate synaptic plasticity. 5-HT(1A) receptors (5-HT(1A)Rs) and dopaminergic type D1 receptors are highly r...

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Detalles Bibliográficos
Autores principales: Meunier, Claire Nicole Jeanne, Callebert, Jacques, Cancela, José-Manuel, Fossier, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361673/
https://www.ncbi.nlm.nih.gov/pubmed/25775449
http://dx.doi.org/10.1371/journal.pone.0120286