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DAF-16 target identification in C. elegans: past, present and future
In C. elegans, mutations in the conserved insulin/IGF-1 signaling (IIS) pathway lead to a robust extension in lifespan, improved late life health, and protection from age-related disease. These effects are mediated by the FoxO transcription factor DAF-16 which lies downstream of the IIS kinase casca...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer Netherlands
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361755/ https://www.ncbi.nlm.nih.gov/pubmed/25156270 http://dx.doi.org/10.1007/s10522-014-9527-y |