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DAF-16 target identification in C. elegans: past, present and future

In C. elegans, mutations in the conserved insulin/IGF-1 signaling (IIS) pathway lead to a robust extension in lifespan, improved late life health, and protection from age-related disease. These effects are mediated by the FoxO transcription factor DAF-16 which lies downstream of the IIS kinase casca...

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Detalles Bibliográficos
Autor principal:	Tullet, Jennifer M. A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Netherlands 2014
Materias:	Review Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361755/ https://www.ncbi.nlm.nih.gov/pubmed/25156270 http://dx.doi.org/10.1007/s10522-014-9527-y

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