ITCH modulates SIRT6 and SREBP2 to influence lipid metabolism and atherosclerosis in ApoE null mice

Atherosclerosis is a chronic inflammatory disease characterized by the infiltration of pro-inflammatory macrophages into a lipid-laden plaque. ITCH is an E3 ubiquitin ligase that has been shown to polarize macrophages to an anti-inflammatory phenotype. We therefore investigated the effect of ITCH de...

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Detalles Bibliográficos
Autores principales: Stöhr, R., Mavilio, M., Marino, A., Casagrande, V., Kappel, B., Möllmann, J., Menghini, R., Melino, G., Federici, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361881/
https://www.ncbi.nlm.nih.gov/pubmed/25777360
http://dx.doi.org/10.1038/srep09023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361881/
https://www.ncbi.nlm.nih.gov/pubmed/25777360
http://dx.doi.org/10.1038/srep09023

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