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ITCH modulates SIRT6 and SREBP2 to influence lipid metabolism and atherosclerosis in ApoE null mice

Atherosclerosis is a chronic inflammatory disease characterized by the infiltration of pro-inflammatory macrophages into a lipid-laden plaque. ITCH is an E3 ubiquitin ligase that has been shown to polarize macrophages to an anti-inflammatory phenotype. We therefore investigated the effect of ITCH de...

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Detalles Bibliográficos
Autores principales:	Stöhr, R., Mavilio, M., Marino, A., Casagrande, V., Kappel, B., Möllmann, J., Menghini, R., Melino, G., Federici, M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361881/ https://www.ncbi.nlm.nih.gov/pubmed/25777360 http://dx.doi.org/10.1038/srep09023

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