Distinct transduction profiles in the CNS via three injection routes of AAV9 and the application to generation of a neurodegenerative mouse model

Using single-stranded adeno-associated virus serotype 9 (ssAAV9) vectors containing the neuron-specific synapsin-I promoter, we examined whether different administration routes (direct cerebellar cortical (DC), intrathecal (IT) and intravenous (IV) injections) could elicit specific transduction prof...

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Detalles Bibliográficos
Autores principales: Huda, Fathul, Konno, Ayumu, Matsuzaki, Yasunori, Goenawan, Hanna, Miyake, Koichi, Shimada, Takashi, Hirai, Hirokazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362361/
https://www.ncbi.nlm.nih.gov/pubmed/26015973
http://dx.doi.org/10.1038/mtm.2014.32

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362361/
https://www.ncbi.nlm.nih.gov/pubmed/26015973
http://dx.doi.org/10.1038/mtm.2014.32

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