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Developmental stage determines efficiency of gene transfer to muscle satellite cells by in utero delivery of adeno-associated virus vector serotype 2/9
Efficient gene transfer to muscle stem cells (satellite cells) has not been achieved despite broad transduction of skeletal muscle by systemically administered adeno-associated virus serotype 2/9 (AAV-9) in mice. We hypothesized that cellular migration during fetal development would make satellite c...
Autores principales: | Stitelman, David H, Brazelton, Tim, Bora, Archana, Traas, Jeremy, Merianos, Demetri, Limberis, Maria, Davey, Marcus, Flake, Alan W |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362369/ https://www.ncbi.nlm.nih.gov/pubmed/26015979 http://dx.doi.org/10.1038/mtm.2014.40 |
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