Cargando…
Pre-TCRα supports CD3-dependent reactivation and expansion of TCRα-deficient primary human T-cells
Chimeric antigen receptor technology offers a highly effective means for increasing the anti-tumor effects of autologous adoptive T-cell immunotherapy, and could be made widely available if adapted to the use of allogeneic T-cells. Although gene-editing technology can be used to remove the alloreact...
Autores principales: | Galetto, Román, Lebuhotel, Celine, Poirot, Laurent, Gouble, Agnès, Toribio, Maria L, Smith, Julianne, Scharenberg, Andrew |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362381/ https://www.ncbi.nlm.nih.gov/pubmed/26015965 http://dx.doi.org/10.1038/mtm.2014.21 |
Ejemplares similares
-
Pre-T cell receptor for improved expansion of TCR alpha disrupted T cells
por: Galetto, Roman, et al.
Publicado: (2013) -
Treatment of B cells malignancies with anti-CD19 CAR+, TCR-, CD52- allogeneic T cells
por: Mannioui, Cécile Schiffer, et al.
Publicado: (2013) -
Allogeneic TCRαβ deficient CAR T-cells targeting CD123 in acute myeloid leukemia
por: Sugita, Mayumi, et al.
Publicado: (2022) -
Pre-TCRα and TCRα Are Not Interchangeable Partners of TCRβ during T Lymphocyte Development
por: Borowski, Christine, et al.
Publicado: (2004) -
An Endoplasmic Reticulum Retention Function for the Cytoplasmic Tail of the Human Pre–T Cell Receptor (Tcr) α Chain: Potential Role in the Regulation of Cell Surface Pre-Tcr Expression Levels
por: Carrasco, Yolanda R., et al.
Publicado: (2001)