JAK2(V617F) Drives Mcl-1 Expression and Sensitizes Hematologic Cell Lines to Dual Inhibition of JAK2 and Bcl-xL

Constitutive activation of the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) axis is fundamental to the molecular pathogenesis of a host of hematological disorders, including acute leukemias and myeloproliferative neoplasms (MPN). We demonstrate here that the major JAK2...

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Detalles Bibliográficos
Autores principales: Guo, Jun, Roberts, Lisa, Chen, Zhui, Merta, Philip J., Glaser, Keith B., Shah, O. Jameel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362760/
https://www.ncbi.nlm.nih.gov/pubmed/25781882
http://dx.doi.org/10.1371/journal.pone.0114363

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362760/
https://www.ncbi.nlm.nih.gov/pubmed/25781882
http://dx.doi.org/10.1371/journal.pone.0114363

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