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The Role of Poly(ADP-ribosyl)ation in DNA Damage Response and Cancer Chemotherapy
DNA damage is a deleterious threat, but occurs daily in all types of cells. In response to DNA damage, poly(ADP-ribosyl)ation, a unique posttranslational modification, is immediately catalyzed by poly(ADP-ribose) polymerases (PARPs) at DNA lesions, which facilitates DNA damage repair. Recent studies...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362780/ https://www.ncbi.nlm.nih.gov/pubmed/25220415 http://dx.doi.org/10.1038/onc.2014.295 |