DISC1 regulates trafficking and processing of APP and Aβ generation

We report the novel regulation of proteolytic processing of amyloid precursor protein (APP) by DISC1, a major risk factor for psychiatric illnesses, such as depression and schizophrenia. RNAi-knockdown of DISC1 in mature primary cortical neurons led to a significant increase in the levels of intrace...

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Detalles Bibliográficos
Autores principales: Shahani, Neelam, Seshadri, Saurav, Jaaro-Peled, Hanna, Ishizuka, Koko, Hirota-Tsuyada, Yuki, Wang, Qi, Koga, Minori, Sedlak, Thomas W., Korth, Carsten, Brandon, Nicholas J., Kamiya, Atsushi, Subramaniam, Srinivasa, Tomoda, Toshifumi, Sawa, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362789/
https://www.ncbi.nlm.nih.gov/pubmed/25224257
http://dx.doi.org/10.1038/mp.2014.100

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362789/
https://www.ncbi.nlm.nih.gov/pubmed/25224257
http://dx.doi.org/10.1038/mp.2014.100

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