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DISC1 regulates trafficking and processing of APP and Aβ generation
We report the novel regulation of proteolytic processing of amyloid precursor protein (APP) by DISC1, a major risk factor for psychiatric illnesses, such as depression and schizophrenia. RNAi-knockdown of DISC1 in mature primary cortical neurons led to a significant increase in the levels of intrace...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362789/ https://www.ncbi.nlm.nih.gov/pubmed/25224257 http://dx.doi.org/10.1038/mp.2014.100 |