Inhibition of NF-kappa B signaling restores responsiveness of castrate resistant prostate cancer cells to anti-androgen treatment by decreasing androgen receptor variants expression

Androgen receptor splicing variants (ARVs) which lack the ligand-binding domain (LBD) are associated with the development of castration-resistant prostate cancer (CRPC), including resistance to the new generation of high affinity anti-androgens. However, the mechanism by which ARVs expression is reg...

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Detalles Bibliográficos
Autores principales: Jin, Renjie, Yamashita, Hironobu, Yu, Xiuping, Wang, Jingbin, Franco, Omar E., Wang, Yufen, Hayward, Simon W., Matusik, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362792/
https://www.ncbi.nlm.nih.gov/pubmed/25220414
http://dx.doi.org/10.1038/onc.2014.302

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362792/
https://www.ncbi.nlm.nih.gov/pubmed/25220414
http://dx.doi.org/10.1038/onc.2014.302

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