Pro-apoptotic and pro-autophagic effects of the Aurora kinase A inhibitor alisertib (MLN8237) on human osteosarcoma U-2 OS and MG-63 cells through the activation of mitochondria-mediated pathway and inhibition of p38 MAPK/PI3K/Akt/mTOR signaling pathway

Osteosarcoma (OS) is the most common malignant bone tumor occurring mostly in children and adolescents between 10 and 20 years of age with poor response to current therapeutics. Alisertib (ALS, MLN8237) is a selective Aurora kinase A inhibitor that displays anticancer effects on several types of can...

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Detalles Bibliográficos
Autores principales: Niu, Ning-Kui, Wang, Zi-Li, Pan, Shu-Ting, Ding, Hui-Qiang, Au, Giang HT, He, Zhi-Xu, Zhou, Zhi-Wei, Xiao, Guozhi, Yang, Yin-Xue, Zhang, Xueji, Yang, Tianxin, Chen, Xiao-Wu, Qiu, Jia-Xuan, Zhou, Shu-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362906/
https://www.ncbi.nlm.nih.gov/pubmed/25792811
http://dx.doi.org/10.2147/DDDT.S74197

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362906/
https://www.ncbi.nlm.nih.gov/pubmed/25792811
http://dx.doi.org/10.2147/DDDT.S74197

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