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Total Synthesis of Vinblastine, Related Natural Products, and Key Analogues and Development of Inspired Methodology Suitable for the Systematic Study of Their Structure–Function Properties

[Image: see text] Biologically active natural products composed of fascinatingly complex structures are often regarded as not amenable to traditional systematic structure–function studies enlisted in medicinal chemistry for the optimization of their properties beyond what might be accomplished by se...

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Detalles Bibliográficos
Autores principales: Sears, Justin E., Boger, Dale L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363169/
https://www.ncbi.nlm.nih.gov/pubmed/25586069
http://dx.doi.org/10.1021/ar500400w