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CENP-A nucleosomes localize to transcription factor hotspots and subtelomeric sites in human cancer cells
BACKGROUND: The histone H3 variant CENP-A is normally tightly regulated to ensure only one centromere exists per chromosome. Native CENP-A is often found overexpressed in human cancer cells and a range of human tumors. Consequently, CENP-A misregulation is thought to contribute to genome instability...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363203/ https://www.ncbi.nlm.nih.gov/pubmed/25788983 http://dx.doi.org/10.1186/1756-8935-8-2 |