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Prion-like Mechanism in Amyotrophic Lateral Sclerosis: are Protein Aggregates the Key?
ALS is a fatal adult-onset motor neuron disease. Motor neurons in the cortex, brain stem and spinal cord gradually degenerate in ALS patients, and most ALS patients die within 3~5 years of disease onset due to respiratory failure. The major pathological hallmark of ALS is abnormal accumulation of pr...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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The Korean Society for Brain and Neural Science
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363329/ https://www.ncbi.nlm.nih.gov/pubmed/25792864 http://dx.doi.org/10.5607/en.2015.24.1.1 |