Molecular Dynamics Simulation and Experimental Verification of the Interaction between Cyclin T1 and HIV-1 Tat Proteins

The viral encoded Tat protein is essential for the transcriptional activation of HIV proviral DNA. Interaction of Tat with a cellular transcription elongation factor P-TEFb containing CycT1 is critically required for its action. In this study, we performed MD simulation using the 3D data for wild-ty...

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Detalles Bibliográficos
Autores principales: Asamitsu, Kaori, Hirokawa, Takatsugu, Hibi, Yurina, Okamoto, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363469/
https://www.ncbi.nlm.nih.gov/pubmed/25781978
http://dx.doi.org/10.1371/journal.pone.0119451

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363469/
https://www.ncbi.nlm.nih.gov/pubmed/25781978
http://dx.doi.org/10.1371/journal.pone.0119451

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