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The Transcription Factor C-Myc Suppresses MiR-23b and MiR-27b Transcription during Fetal Distress and Increases the Sensitivity of Neurons to Hypoxia-Induced Apoptosis
Previous studies reported that the expression of miR-23b-27b cluster was downregulated in embryonic brain cortices during hypoxia-induced neuronal apoptosis. However, the mechanism underlying this downregulation is not completely understood. Here, we report that the transcription factor c-Myc plays...
Autores principales: | Chen, Qun, Zhang, Fan, Wang, Yanbo, Liu, Zhengya, Sun, Anyang, Zen, Ke, Zhang, Chen-yu, Zhang, Qipeng |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363589/ https://www.ncbi.nlm.nih.gov/pubmed/25781629 http://dx.doi.org/10.1371/journal.pone.0120217 |
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