Cargando…

High Frequency of Transmitted HIV-1 Gag HLA Class I-Driven Immune Escape Variants but Minimal Immune Selection over the First Year of Clade C Infection

In chronic HIV infection, CD8+ T cell responses to Gag are associated with lower viral loads, but longitudinal studies of HLA-restricted CD8+ T cell-driven selection pressure in Gag from the time of acute infection are limited. In this study we examined Gag sequence evolution over the first year of...

Descripción completa

Detalles Bibliográficos
Autores principales: Gounder, Kamini, Padayachi, Nagavelli, Mann, Jaclyn K., Radebe, Mopo, Mokgoro, Mammekwa, van der Stok, Mary, Mkhize, Lungile, Mncube, Zenele, Jaggernath, Manjeetha, Reddy, Tarylee, Walker, Bruce D., Ndung’u, Thumbi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363590/
https://www.ncbi.nlm.nih.gov/pubmed/25781986
http://dx.doi.org/10.1371/journal.pone.0119886