Deletion of PDK1 Causes Cardiac Sodium Current Reduction in Mice

BACKGROUND: The AGC protein kinase family regulates multiple cellular functions. 3-phosphoinositide-dependent protein kinase-1 (PDK1) is involved in the pathogenesis of arrhythmia, and its downstream factor, Forkhead box O1 (Foxo1), negatively regulates the expression of the cardiac sodium channel,...

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Detalles Bibliográficos
Autores principales: Han, Zhonglin, Jiang, Yu, Yang, Yuqing, Li, Xuehan, Yang, Zhongzhou, Cao, Kejiang, Wang, Dao W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363661/
https://www.ncbi.nlm.nih.gov/pubmed/25781322
http://dx.doi.org/10.1371/journal.pone.0122436

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363661/
https://www.ncbi.nlm.nih.gov/pubmed/25781322
http://dx.doi.org/10.1371/journal.pone.0122436

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